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Cyp19a1tm1Toda
Targeted Allele Detail
Summary
Symbol: Cyp19a1tm1Toda
Name: cytochrome P450, family 19, subfamily a, polypeptide 1; targeted mutation 1, Katsumi Toda
MGI ID: MGI:2179439
Synonyms: Ar-, ArKO
Gene: Cyp19a1  Location: Chr9:54073221-54175394 bp, - strand  Genetic Position: Chr9, 29.49 cM
Alliance: Cyp19a1tm1Toda page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:79603
Parent Cell Line:  E14.1 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation details87 nucleotides of exon 9 were replaced with a neomycin resistance gene via homologous recombination. Northern blot of gene transcripts from ovaries of homozygous mutant animals verified the absence of exon 9 and enzyme assay detected negligible levels of enzyme activity. (J:70359)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 19 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Cyp19a1 Mutation:  34 strains or lines available
References
Original:  J:79603 Nemoto Y, et al., Altered expression of fatty acid-metabolizing enzymes in aromatase-deficient mice. J Clin Invest. 2000 Jun;105(12):1819-25
All:  23 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/19/2024
MGI 6.23
The Jackson Laboratory