Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Smyd1tm1Dsr
Name:	SET and MYND domain containing 1; targeted mutation 1, Deepak Srivastava
MGI ID:	MGI:2179298
Synonyms:	Bop-
Gene:	Smyd1  Location: Chr6:71190924-71239265 bp, - strand  Genetic Position: Chr6, 32.14 cM
Alliance:	Smyd1tm1Dsr page

Germline Transmission:	Earliest citation of germline transmission: J:76212
Parent Cell Line:	SM1 (ES Cell)
Strain of Origin:	129S6/SvEvTac

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: Exons 2 and 3, which encompass the MYND domain, are replaced with a neo-resistance gene. RT-PCR failed to detect transcript in hearts from homozygous mutant embryos at E9.5 (J:76212)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

4 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Smyd1 Mutation:	45 strains or lines available

Original:	J:76212 Gottlieb PD, et al., Bop encodes a muscle-restricted protein containing MYND and SET domains and is essential for cardiac differentiation and morphogenesis. Nat Genet. 2002 May;31(1):25-32
All:	1 reference(s)