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Rhbdl3 Gene Detail
Summary
  • Symbol
    Rhbdl3
  • Name
    rhomboid like 3
  • Synonyms
    Rhbdl4, Ventrhoid, Vrho
  • Feature Type
    protein coding gene
  • IDs
    MGI:2179276
    NCBI Gene: 246104
  • Alliance
    gene page
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr11:80191738-80246781 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 11, 47.73 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    210 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2179276
 protein coding gene Chr11:80191296-80246812 (+)
129S1/SvImJ MGP_129S1SvImJ_G0018810
 protein coding gene Chr11:81455987-81512158 (+)
A/J MGP_AJ_G0018777
 protein coding gene Chr11:78330798-78386298 (+)
AKR/J MGP_AKRJ_G0018747
 protein coding gene Chr11:80680104-80738174 (+)
BALB/cJ MGP_BALBcJ_G0018750
 protein coding gene Chr11:78717964-78773818 (+)
C3H/HeJ MGP_C3HHeJ_G0018564
 protein coding gene Chr11:80728129-80787237 (+)
C57BL/6NJ MGP_C57BL6NJ_G0019202
 protein coding gene Chr11:83949606-84005146 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0016836
 protein coding gene Chr11:75263276-75318422 (+)
CAST/EiJ MGP_CASTEiJ_G0018119
 protein coding gene Chr11:81220964-81276534 (+)
CBA/J MGP_CBAJ_G0018535
 protein coding gene Chr11:87611454-87674143 (+)
DBA/2J MGP_DBA2J_G0018643
 protein coding gene Chr11:77884329-77940267 (+)
FVB/NJ MGP_FVBNJ_G0018632
 protein coding gene Chr11:77448663-77505069 (+)
LP/J MGP_LPJ_G0018713
 protein coding gene Chr11:81973551-82034910 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0018659
 protein coding gene Chr11:87889656-87946786 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0019242
 protein coding gene Chr11:80934544-80990052 (+)
PWK/PhJ MGP_PWKPhJ_G0017889
 protein coding gene Chr11:78694026-78750269 (+)
SPRET/EiJ MGP_SPRETEiJ_G0017680
 protein coding gene Chr11:80526408-80584164 (+)
WSB/EiJ MGP_WSBEiJ_G0018171
 protein coding gene Chr11:80766625-80825488 (+)



Homology
more
  • Human Ortholog
    RHBDL3, rhomboid like 3
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    RHBDL3, rhomboid like 3
  • Synonyms
    RHBDL4, VRHO
  • Links
    NCBI Gene ID: 162494
    neXtProt AC: NX_P58872
    UniProt: P58872

  • Chr Location
    17q11.2; chr17:32265832-32324661 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    2 phenotypes from 1 allele in 1 genetic background
    15 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    4
  • GO References
    4
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    818
  • Tissues
    71
  • cDNA Data
    32
  • Literature Summary
    8
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000017692 Ensembl Gene Model | MGI Sequence Detail 55044 C57BL/6J ±  kb
transcript ENSMUST00000017836 Ensembl | MGI Sequence Detail 3736 Not Applicable  
polypeptide ENSMUSP00000017836 Ensembl | MGI Sequence Detail 404 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 32
    cDNA 32

    Microarray probesets 3
Other
Accession IDs
less
MGI:2144292
References
more
  • Summaries
    All 46
    Developmental Gene Expression 8
    Gene Ontology 4
    Phenotypes 15
  • Earliest
    J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
  • Latest
    J:346394 Knopf JD, et al., RHBDL4-triggered downregulation of COPII adaptor protein TMED7 suppresses TLR4-mediated inflammatory signaling. Nat Commun. 2024 Mar 7;15(1):1528
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
04/09/2024
MGI 6.23 		The Jackson Laboratory