Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Polmtm1Crey
Name:	polymerase (DNA directed), mu; targeted mutation 1, Claude-Agnes Reynaud
MGI ID:	MGI:2179233
Synonyms:	pol mu-
Gene:	Polm  Location: Chr11:5777860-5788016 bp, - strand  Genetic Position: Chr11, 3.87 cM
Alliance:	Polmtm1Crey page

Germline Transmission:	Earliest citation of germline transmission: J:75927
Parent Cell Line:	E14.1 (ES Cell)
Strain of Origin:	129P2/OlaHsd

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: Exons 7-9 were replaced with a neomycin resistance gene via homologous recombination resulting in truncation of exons 6 and 10 and loss of most of the polX domain. RT-PCR of spleen B cells from homozygous mutant animals failed to detect gene expression. (J:75927)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

1 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Polm Mutation:	28 strains or lines available

Original:	J:75927 Bertocci B, et al., Cutting edge: DNA polymerases mu and lambda are dispensable for Ig gene hypermutation. J Immunol. 2002 Apr 15;168(8):3702-6
All:	3 reference(s)