Summary | Mutation origin | Mutation description | Expression | Phenotypes | Tumor data | Find Mice (IMSR) | References

Symbol:	E2f2tm1Zubi
Name:	E2F transcription factor 2; targeted mutation 1, Ana Zubiaga
MGI ID:	MGI:2179111
Synonyms:	E2F2-, E2f2tm1Gle
Gene:	E2f2  Location: Chr4:135899705-135923368 bp, + strand  Genetic Position: Chr4, 68.34 cM, cytoband D3
Alliance:	E2f2tm1Zubi page

Germline Transmission:	Earliest citation of germline transmission: J:75726
Parent Cell Line:	CJ7 (ES Cell)
Strain of Origin:	129S1/Sv-Oca2+ Tyr+ Kitl+

Allele Type:    Targeted (Null/knockout) Mutation:    Insertion   Mutation details: A PGK-neo cassette was inserted into exon 3. Southern and Northern analysis was utilized to confirm the targeting event and lack of transcript in homozygous mutant animals, respectively. (J:75726, J:76318)

View phenotypes and curated references for all genotypes (concatenated display).

In Mice Carrying this Mutation:	72 assay results 1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	6 anatomical structure(s)

List all tumor models in MMHCdb carrying E2f2tm1Zubi

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any E2f2 Mutation:	29 strains or lines available

Original:	J:75726 Leone G, et al., Myc requires distinct E2F activities to induce S phase and apoptosis. Mol Cell. 2001 Jul;8(1):105-13
All:	45 reference(s)