Summary | Mutation origin | Mutation description | Phenotypes | Find Mice (IMSR) | References

Symbol:	Serpind1tm1Toll
Name:	serine (or cysteine) peptidase inhibitor, clade D, member 1; targeted mutation 1, Douglas M Tollefsen
MGI ID:	MGI:2179102
Synonyms:	HCII-
Gene:	Serpind1  Location: Chr16:17149235-17161438 bp, + strand  Genetic Position: Chr16, 10.74 cM
Alliance:	Serpind1tm1Toll page

Germline Transmission:	Earliest citation of germline transmission: J:74337
Parent Cell Line:	RW-4 (ES Cell)
Strain of Origin:	129X1/SvJ

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: Exon 1 of this gene was replaced with a neomycin cassette via homologous recombination. Northern blot of liver from homozygous mutant animals detected a mutant transcript containing the neo sequence. Plasma from homozygous mutant animals did not contain protein product or exhibit enzyme activity. (J:74337)

View phenotypes and curated references for all genotypes (concatenated display).

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 2 strains available      Cell Lines: 0 lines available
Carrying any Serpind1 Mutation:	21 strains or lines available

Original:	J:74337 He L, et al., Heparin cofactor II inhibits arterial thrombosis after endothelial injury. J Clin Invest. 2002 Jan;109(2):213-9
All:	6 reference(s)