Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol: Wnt3tm1Brd Name: wingless-type MMTV integration site family, member 3; targeted mutation 1, Allan Bradley MGI ID: MGI:2178826 Synonyms: Wnt3-, Wnt3n Gene: Wnt3  Location: Chr11:103664976-103708783 bp, + strand  Genetic Position: Chr11, 67.5 cM Alliance: Wnt3tm1Brd page

Decrease in the number of Dppa3+ primordial germ cells in Ctdnep1tm1Ryn/Ctdnep1+ Wnt3tm1Brd/Wnt3+ embryos Show the 1 phenotype image(s) involving this allele.

Germline Transmission:	Earliest citation of germline transmission: J:56511
Parent Cell Line:	AB2.2 (ES Cell)
Strain of Origin:	129S7/SvEvBrd-Hprt1b-m2

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: Exon 3 and most of exon 4 of this gene was replaced with a puromycin-HPRT cassette via homologous recombination. PCR analysis was used to detect homozygous mutant embryos. (J:56511)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

7 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Wnt3 Mutation:	25 strains or lines available

Original:	J:56511 Liu P, et al., Requirement for Wnt3 in vertebrate axis formation. Nat Genet. 1999 Aug;22(4):361-5
All:	12 reference(s)