Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Wipf1tm1Geha
Name:	WAS/WASL interacting protein family, member 1; targeted mutation 1, Raif S Geha
MGI ID:	MGI:2178802
Synonyms:	WIP-
Gene:	Wipf1  Location: Chr2:73259954-73359831 bp, - strand  Genetic Position: Chr2, 43.68 cM
Alliance:	Wipf1tm1Geha page

Germline Transmission:	Earliest citation of germline transmission: J:74719
Parent Cell Line:	TC1/TC-1 (ES Cell)
Strain of Origin:	129S6/SvEvTac

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: Exons 2 and 5 of this gene were replaced with a neo resistance gene via homologous recombination. Southern blot confirmed successful targeting of the construct in TC-1 ES cells. Western blot of thymocyte, lymph node, and splenocyte lysates confirmed the absence of protein product in homozygous mutant animals. (J:74719)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

12 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Wipf1 Mutation:	29 strains or lines available

Original:	J:74719 Anton IM, et al., WIP Deficiency Reveals a Differential Role for WIP and the Actin Cytoskeleton in T and B Cell Activation. Immunity. 2002 Feb;16(2):193-204
All:	13 reference(s)