Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Drd4tm1Dkg
Name:	dopamine receptor D4; targeted mutation 1, David K Grandy
MGI ID:	MGI:2178631
Synonyms:	D4-, D4KO, D4R -, Drd4-
Gene:	Drd4  Location: Chr7:140871931-140874868 bp, + strand  Genetic Position: Chr7, 86.6 cM
Alliance:	Drd4tm1Dkg page

Germline Transmission:	Earliest citation of germline transmission: J:43061
Parent Cell Line:	E14TG2a (ES Cell)
Strain of Origin:	129P2/OlaHsd

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: A neomycin resistance cassette replaced exon 2. RT-PCR analysis demonstrated that a mutated transcript was produced from this allele that spliced exon 1 to exon 3. This mutation causes a shift in the reading frame that is predicted to result in the production of a truncated protein. (J:43061)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

1 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Drd4 Mutation:	31 strains or lines available

Original:	J:43061 Rubinstein M, et al., Mice lacking dopamine D4 receptors are supersensitive to ethanol, cocaine, and methamphetamine. Cell. 1997 Sep 19;90(6):991-1001
All:	39 reference(s)