Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Crhr2tm1Mpsp
Name:	corticotropin releasing hormone receptor 2; targeted mutation 1, Mary P Stenzel-Poore
MGI ID:	MGI:2178619
Synonyms:	CRF2 KO
Gene:	Crhr2  Location: Chr6:55067034-55110001 bp, - strand  Genetic Position: Chr6, 27.33 cM
Alliance:	Crhr2tm1Mpsp page

Germline Transmission:	Earliest citation of germline transmission: J:61510
Parent Cell Line:	RW-4 (ES Cell)
Strain of Origin:	129X1/SvJ

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: The exons encoding transmembrane domains 3-5 and surrounding sequence were replaced with a neo cassette via homologous recombination. (J:61510)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

2 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Crhr2 Mutation:	34 strains or lines available

Original:	J:61510 Coste SC, et al., Abnormal adaptations to stress and impaired cardiovascular function in mice lacking corticotropin-releasing hormone receptor-2. Nat Genet. 2000 Apr;24(4):403-9
All:	16 reference(s)