Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Crhr2tm1Jsp
Name:	corticotropin releasing hormone receptor 2; targeted mutation 1, Joachim Speiss
MGI ID:	MGI:2178616
Synonyms:	Crhr2-
Gene:	Crhr2  Location: Chr6:55067034-55110001 bp, - strand  Genetic Position: Chr6, 27.33 cM
Alliance:	Crhr2tm1Jsp page

Germline Transmission:	Earliest citation of germline transmission: J:61485
Parent Cell Line:	R1 (ES Cell)
Strain of Origin:	(129X1/SvJ x 129S1/Sv)F1-Kitl+

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: A neomycin selection cassette replaced a genomic fragment containing exons which encode the third intracelllular loop. Binding assays on sections of adult homozygous brain confirmed that no functional protein was expressed from this allele. No detectable transcript was produced from this allele (data not shown). (J:61485)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

2 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 2 strains available      Cell Lines: 0 lines available
Carrying any Crhr2 Mutation:	34 strains or lines available

Original:	J:61485 Kishimoto T, et al., Deletion of crhr2 reveals an anxiolytic role for corticotropin-releasing hormone receptor-2. Nat Genet. 2000 Apr;24(4):415-9
All:	3 reference(s)