Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Mycntm1Fwa
Name:	v-myc avian myelocytomatosis viral related oncogene, neuroblastoma derived; targeted mutation 1, Frederick W Alt
MGI ID:	MGI:2178216
Synonyms:	N-myc-
Gene:	Mycn  Location: Chr12:12986094-12991837 bp, - strand  Genetic Position: Chr12, 6.14 cM, cytoband A3-B
Alliance:	Mycntm1Fwa page

Germline Transmission:	Earliest citation of germline transmission: J:3413
Parent Cell Line:	CCE/EK.CCE (ES Cell)
Strain of Origin:	129S/SvEv-Gpi1c

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: A neomycin selection cassette replaced part of exon 2. Northern blot analysis confirmed absence of wild-type transcripts in homozygous mutant embryos at E10.5. (J:3413)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

10 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Mycn Mutation:	24 strains or lines available

Original:	J:3413 Charron J, et al., Embryonic lethality in mice homozygous for a targeted disruption of the N-myc gene. Genes Dev. 1992 Dec;6(12A):2248-57
All:	2 reference(s)