Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol: Serpinc1tm1Sai Name: serine (or cysteine) peptidase inhibitor, clade C (antithrombin), member 1; targeted mutation 1, Hidehiko Saito MGI ID: MGI:2178128 Synonyms: AT-, ATIII- Gene: Serpinc1  Location: Chr1:160806153-160830113 bp, + strand  Genetic Position: Chr1, 69.75 cM Alliance: Serpinc1tm1Sai page

Subcutaneous hemorrhage in Serpinc1tm1Sai/Serpinc1tm1Sai mice Show the 3 phenotype image(s) involving this allele.

Germline Transmission:	Earliest citation of germline transmission: J:65092
Parent Cell Line:	D3 (ES Cell)
Strain of Origin:	129S2/SvPas

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: A neomycin resistance cassette replaced exon 2 and flanking intronic sequences. RT-PCR analysis on RNA derived from homozygous embryos demonstrated that no detectable transcript was produced from this allele, and western blot analysis on liver lysates confirmed that no protein was expressed from this allele. (J:65092)

View phenotypes and curated references for all genotypes (concatenated display).

In Mice Carrying this Mutation:	15 assay results
In Structures Affected by this Mutation:	1 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Serpinc1 Mutation:	27 strains or lines available

Original:	J:65092 Ishiguro K, et al., Complete antithrombin deficiency in mice results in embryonic lethality. J Clin Invest. 2000 Oct;106(7):873-8
All:	4 reference(s)