Summary | Mutation origin | Mutation description | Phenotypes | Find Mice (IMSR) | References

Symbol:	F3tm1Dwr
Name:	coagulation factor III; targeted mutation 1, Mieke Dewerchin
MGI ID:	MGI:2178047
Synonyms:	TFneo
Gene:	F3  Location: Chr3:121517186-121528697 bp, + strand  Genetic Position: Chr3, 52.94 cM
Alliance:	F3tm1Dwr page

Germline Transmission:	Earliest citation of germline transmission: J:71271
Parent Cell Line:	R1 (ES Cell)
Strain of Origin:	(129X1/SvJ x 129S1/Sv)F1-Kitl+

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: Part of exon 6, encoding the last 18 amino acids, was deleted. In addition, a loxP-flanked neomycin resistance cassette was inserted into exon 5. Northen blot analysis confirmed the expression of a fusion transcript with the 3'UTR and neo cassette. (J:71271)

View phenotypes and curated references for all genotypes (concatenated display).

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any F3 Mutation:	24 strains or lines available

Original:	J:71271 Melis E, et al., Targeted deletion of the cytosolic domain of tissue factor in mice does not affect development. Biochem Biophys Res Commun. 2001 Aug 24;286(3):580-6
All:	2 reference(s)