Summary | Mutation origin | Mutation description | Expression | Phenotypes | Disease models | Find Mice (IMSR) | References

Symbol: Pin1tm1Tuc Name: peptidyl-prolyl cis/trans isomerase, NIMA-interacting 1; targeted mutation 1, Takafumi Uchida MGI ID: MGI:2177943 Synonyms: Pin1- Gene: Pin1  Location: Chr9:20563335-20575008 bp, + strand  Genetic Position: Chr9, 7.6 cM Alliance: Pin1tm1Tuc page

Reduced body weight and testicular atrophy in Pin1tm1Tuc/Pin1tm1Tuc mice Show the 3 phenotype image(s) involving this allele.

Germline Transmission:	Earliest citation of germline transmission: J:58734
Parent Cell Line:	E14 (ES Cell)
Strain of Origin:	129P2/OlaHsd

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: A neomycin resistance cassette replaced exons 1-4, which contain the entire coding sequence of the gene. Western blot analysis on embryonic fibroblasts derived from homozygous mice confirmed that no detectable protein was expressed from this allele. (J:58734)

View phenotypes and curated references for all genotypes (concatenated display).

In Mice Carrying this Mutation:	6 assay results 2 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	5 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 2 strains available      Cell Lines: 0 lines available
Carrying any Pin1 Mutation:	17 strains or lines available

Original:	J:58734 Fujimori F, et al., Mice lacking Pin1 develop normally, but are defective in entering cell cycle from G(0) arrest. Biochem Biophys Res Commun. 1999 Nov 30;265(3):658-63
All:	72 reference(s)