Gabrb2tm1.1Twr
Targeted Allele Detail
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Symbol: |
Gabrb2tm1.1Twr |
Name: |
gamma-aminobutyric acid type A receptor subunit beta 2; targeted mutation 1.1, Thomas W Rosahl |
MGI ID: |
MGI:2177615 |
Synonyms: |
beta2-[-neo] - |
Gene: |
Gabrb2 Location: Chr11:42310584-42519855 bp, + strand Genetic Position: Chr11, 25.08 cM
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Alliance: |
Gabrb2tm1.1Twr page
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Germline Transmission: |
Earliest citation of germline transmission:
J:69290
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Parent Cell Line: |
AB2.2 (ES Cell)
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Strain of Origin: |
129S7/SvEvBrd-Hprt1b-m2
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Allele Type: |
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Targeted (Null/knockout) |
Mutations: |
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Insertion, Intragenic deletion
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Mutation details: A genomic fragment containing exon 7 was replaced with a loxP flanked neomycin selection cassette. The resistance cassete was removed in the germline by Cre mediated recombination. Northern blot analysis on RNA derived from homozygous mice demonstrated that no detectable transcript was produced from this allele.
(J:69290)
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View phenotypes and curated references for all genotypes (concatenated display).
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Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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Carrying any Gabrb2 Mutation: |
43 strains or lines available
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Original: |
J:69290 Sur C, et al., Loss of the major GABA(A) receptor subtype in the brain is not lethal in mice. J Neurosci. 2001 May 15;21(10):3409-18 |
All: |
5 reference(s) |
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