Summary | Mutation origin | Mutation description | Phenotypes | Find Mice (IMSR) | References

Symbol:	Gabrb2tm1Twr
Name:	gamma-aminobutyric acid type A receptor subunit beta 2; targeted mutation 1, Thomas W Rosahl
MGI ID:	MGI:2177613
Synonyms:	beta2 -
Gene:	Gabrb2  Location: Chr11:42310584-42519855 bp, + strand  Genetic Position: Chr11, 25.08 cM
Alliance:	Gabrb2tm1Twr page

Germline Transmission:	Earliest citation of germline transmission: J:69290
Parent Cell Line:	AB2.2 (ES Cell)
Strain of Origin:	129S7/SvEvBrd-Hprt1b-m2

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: A genomic fragment containing exon 7 was replaced with a loxP flanked neomycin selection cassette. Northern blot analysis on RNA derived from homozygous mice demonstrated that no detectable transcript was produced from this allele. (J:69290)

View phenotypes and curated references for all genotypes (concatenated display).

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Gabrb2 Mutation:	43 strains or lines available

Original:	J:69290 Sur C, et al., Loss of the major GABA(A) receptor subtype in the brain is not lethal in mice. J Neurosci. 2001 May 15;21(10):3409-18
All:	6 reference(s)