Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Zap70tm1Weis
Name:	zeta-chain (TCR) associated protein kinase; targeted mutation 1, Arthur Weiss
MGI ID:	MGI:2176252
Synonyms:	ZAP-70 -
Gene:	Zap70  Location: Chr1:36800879-36821899 bp, + strand  Genetic Position: Chr1, 15.41 cM, cytoband A4-C1
Alliance:	Zap70tm1Weis page

Germline Transmission:	Earliest citation of germline transmission: J:74974
Parent Cell Line:	JM-1 (ES Cell)
Strain of Origin:	129X1/SvJ

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: A neomycin resistance cassette replaced a genomic fragment containing sequences corresponding to amino acids 221 to 520, which encode the C-terminal SH2 domain. Western blot analysis on thymocytes derived from homozygous mice confirmed that no detectable protein is expressed from this allele. (J:74974)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

3 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 2 strains available      Cell Lines: 0 lines available
Carrying any Zap70 Mutation:	55 strains or lines available

Original:	J:74974 Kadlecek TA, et al., Differential requirements for ZAP-70 in TCR signaling and T cell development. J Immunol. 1998 Nov 1;161(9):4688-94
All:	25 reference(s)