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Il17rd Gene Detail
Summary
  • Symbol
    Il17rd
  • Name
    interleukin 17 receptor D
  • Synonyms
    2810004A10Rik, Sef, Sef-S
  • Feature Type
    protein coding gene
  • IDs
    MGI:2159727
    NCBI Gene: 171463
  • Alliance
    gene page
  • Transcription Start Sites
    6 TSS
Location &
Maps
more
  • Sequence Map
    Chr14:26760990-26829243 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 14, 16.09 cM
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    464 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2159727
 protein coding gene Chr14:26760898-26829243 (+)
129S1/SvImJ MGP_129S1SvImJ_G0021089
 protein coding gene Chr14:20038334-20112146 (+)
A/J MGP_AJ_G0021038
 protein coding gene Chr14:19242885-19312953 (+)
AKR/J MGP_AKRJ_G0021015
 protein coding gene Chr14:20297138-20372433 (+)
BALB/cJ MGP_BALBcJ_G0021041
 protein coding gene Chr14:19360579-19429719 (+)
C3H/HeJ MGP_C3HHeJ_G0020825
 protein coding gene Chr14:20145989-20223746 (+)
C57BL/6NJ MGP_C57BL6NJ_G0021474
 protein coding gene Chr14:20867482-20938634 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0019037
 protein coding gene Chr14:19376294-19444518 (+)
CAST/EiJ MGP_CASTEiJ_G0020349
 protein coding gene Chr14:19779041-19857820 (+)
CBA/J MGP_CBAJ_G0020791
 protein coding gene Chr14:21697701-21774094 (+)
DBA/2J MGP_DBA2J_G0020914
 protein coding gene Chr14:19327343-19395838 (+)
FVB/NJ MGP_FVBNJ_G0020897
 protein coding gene Chr14:19288242-19356678 (+)
LP/J MGP_LPJ_G0020982
 protein coding gene Chr14:20330151-20407870 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0020923
 protein coding gene Chr14:21065559-21139790 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0021507
 protein coding gene Chr14:20060522-20131597 (+)
PWK/PhJ MGP_PWKPhJ_G0020098
 protein coding gene Chr14:18725630-18802410 (+)
SPRET/EiJ MGP_SPRETEiJ_G0019921
 protein coding gene Chr14:19554987-19627301 (+)
WSB/EiJ MGP_WSBEiJ_G0020405
 protein coding gene Chr14:20098153-20169459 (+)



Homology
more
  • Human Ortholog
    IL17RD, interleukin 17 receptor D
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    IL17RD, interleukin 17 receptor D
  • Synonyms
    HH18, IL-17RD, IL17RLM, SEF
  • Links
    NCBI Gene ID: 54756
    neXtProt AC: NX_Q8NFM7
    UniProt: Q8NFM7

  • Chr Location
    3p14.3; chr3:57089982-57170317 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with human IL17RD associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    5 phenotypes from 3 alleles in 3 genetic backgrounds
    22 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele are viable and show no obvious phenotype. A subset of mice homozygous for a gene-trapped allele display cochlear nucleus defects and abnormal auditory brainstem responses.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    9
  • GO References
    6
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    894
  • Tissues
    81
  • cDNA Data
    36
  • Literature Summary
    16
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 171463 NCBI Gene Model | MGI Sequence Detail 68254 C57BL/6J ±  kb
    transcript NM_134437 RefSeq | MGI Sequence Detail 8188 C57BL/6  
    polypeptide Q8JZL1 UniProt | EBI | MGI Sequence Detail 738 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 38
      cDNA 37
      Other 1

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGI:1917183, MGI:2145635
    References
    more
    • Summaries
      All 72
      Developmental Gene Expression 16
      Gene Ontology 6
      Phenotypes 22
    • Earliest
      J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
    • Latest
      J:335154 Hirose S, et al., IL-17A expression by both T cells and non-T cells contribute to HSV-IL-2-induced CNS demyelination. Front Immunol. 2023;14:1102486
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    04/09/2024
    MGI 6.23     		The Jackson Laboratory