Summary | Mutation origin | Mutation description | Phenotypes | Find Mice (IMSR) | References

Symbol:	Casp12tm1Yuan
Name:	caspase 12; targeted mutation 1, Junying Yuan
MGI ID:	MGI:2159367
Gene:	Casp12  Location: Chr9:5345430-5373032 bp, + strand  Genetic Position: Chr9, 2.46 cM, cytoband A1
Alliance:	Casp12tm1Yuan page

Germline Transmission:	Earliest citation of germline transmission: J:59337
Parent Cell Line:	J1 (ES Cell)
Strain of Origin:	129S4/SvJae

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: A neomycin resistance gene replaced a segment of intron 3 and exon 4. RT-PCR and western blotting experiments confirmed that no transcript or protein was expressed from this allele (data not shown). (J:59337)

View phenotypes and curated references for all genotypes (concatenated display).

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Casp12 Mutation:	32 strains or lines available

Original:	J:59337 Nakagawa T, et al., Caspase-12 mediates endoplasmic-reticulum-specific apoptosis and cytotoxicity by amyloid-beta. Nature. 2000 Jan 6;403(6765):98-103
All:	5 reference(s)