Summary | Mutation origin | Mutation description | Expression | Phenotypes | Disease models | Find Mice (IMSR) | References

Symbol: Gpc3tm1Fil Name: glypican 3; targeted mutation 1, Jorge Filmus MGI ID: MGI:2159356 Synonyms: Gpc3 - Gene: Gpc3  Location: ChrX:51361303-51702827 bp, - strand  Genetic Position: ChrX, 28.74 cM, cytoband A3.3 Alliance: Gpc3tm1Fil page

Some Gpc3tm1Fil/Y embryos exhibit mandibular hypoplasia Show the 4 phenotype image(s) involving this allele.

Germline Transmission:	Earliest citation of germline transmission: J:73877
Parent Cell Line:	Not Specified (ES Cell)
Strain of Origin:	129

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: A neomycin selection cassette replaced a genomic fragment containing part of the promoter and exon 1. Northern blot analysis on RNA derived from E18.5 embryos confirmed that no detectable transcript was produced from this allele. (J:73877)

View phenotypes and curated references for all genotypes (concatenated display).

In Mice Carrying this Mutation:	16 assay results
In Structures Affected by this Mutation:	11 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Gpc3 Mutation:	17 strains or lines available

Original:	J:73877 Cano-Gauci DF, et al., Glypican-3-deficient mice exhibit developmental overgrowth and some of the abnormalities typical of Simpson-Golabi-Behmel syndrome. J Cell Biol. 1999 Jul 12;146(1):255-64
All:	7 reference(s)