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Il17rc Gene Detail
Summary
  • Symbol
    Il17rc
  • Name
    interleukin 17 receptor C
  • Synonyms
    1110025H02Rik, Il17rl, IL17-RL
  • Feature Type
    protein coding gene
  • IDs
    MGI:2159336
    NCBI Gene: 171095
  • Alliance
    gene page
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    Chr6:113448416-113460124 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 6, 52.77 cM, cytoband E3
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    54 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2159336
 protein coding gene Chr6:113448388-113460124 (+)
129S1/SvImJ MGP_129S1SvImJ_G0031126
 protein coding gene Chr6:115992858-116004614 (+)
A/J MGP_AJ_G0031095
 protein coding gene Chr6:111548477-111560194 (+)
AKR/J MGP_AKRJ_G0031026
 protein coding gene Chr6:114542358-114554061 (+)
BALB/cJ MGP_BALBcJ_G0031106
 protein coding gene Chr6:111494486-111506218 (+)
C3H/HeJ MGP_C3HHeJ_G0030602
 protein coding gene Chr6:69742684-69755734 (-)
C57BL/6NJ MGP_C57BL6NJ_G0031565
 protein coding gene Chr6:118995998-119008822 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0028729
 protein coding gene Chr6:108576421-108588115 (+)
CAST/EiJ MGP_CASTEiJ_G0030213
 protein coding gene Chr6:114988291-115000036 (+)
CBA/J MGP_CBAJ_G0030792
 protein coding gene Chr6:123691362-123703050 (+)
DBA/2J MGP_DBA2J_G0030945
 protein coding gene Chr6:110627885-110639563 (+)
FVB/NJ MGP_FVBNJ_G0030899
 protein coding gene Chr6:109629986-109641667 (+)
LP/J MGP_LPJ_G0031025
 protein coding gene Chr6:116028056-116039908 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0030933
 protein coding gene Chr6:127955778-127967459 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0031592
 protein coding gene Chr6:114556713-114568392 (+)
PWK/PhJ MGP_PWKPhJ_G0029929
 protein coding gene Chr6:109584102-109595927 (+)
SPRET/EiJ MGP_SPRETEiJ_G0029757
 protein coding gene Chr6:113375241-113386958 (+)
WSB/EiJ MGP_WSBEiJ_G0030297
 protein coding gene Chr6:114931333-114943018 (+)



Homology
more
  • Human Ortholog
    IL17RC, interleukin 17 receptor C
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    IL17RC, interleukin 17 receptor C
  • Synonyms
    CANDF9, IL17RL, IL17-RL
  • Links
    NCBI Gene ID: 84818
    neXtProt AC: NX_Q8NAC3
    UniProt: Q8NAC3

  • Chr Location
    3p25.3; chr3:9917074-9933630 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with human IL17RC associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    13 phenotypes from 2 alleles in 3 genetic backgrounds
    33 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a reporter allele exhibit increased interleukin-17 secretion, reduced chemokine expression, and decreased susceptibility to experimental autoimmune encephalomyelitis.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    16
  • GO References
    8
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    822
  • Tissues
    16
  • cDNA Data
    43
  • Literature Summary
    1
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 171095 NCBI Gene Model | MGI Sequence Detail 11709 C57BL/6J ±  kb
    transcript NM_178942 RefSeq | MGI Sequence Detail 2369 Not Specified  
    polypeptide Q8K4C2 UniProt | EBI | MGI Sequence Detail 698 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 45
      cDNA 45

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGI:1923564
    References
    more
    • Summaries
      All 63
      Developmental Gene Expression 1
      Gene Ontology 8
      Phenotypes 33
    • Earliest
      J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
    • Latest
      J:335154 Hirose S, et al., IL-17A expression by both T cells and non-T cells contribute to HSV-IL-2-induced CNS demyelination. Front Immunol. 2023;14:1102486
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    04/16/2024
    MGI 6.23     		The Jackson Laboratory