Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Drd1tm1Stl
Name:	dopamine receptor D1; targeted mutation 1, Susumu Tonegawa
MGI ID:	MGI:2159306
Synonyms:	D1-, D1R-
Gene:	Drd1  Location: Chr13:54205202-54209677 bp, - strand  Genetic Position: Chr13, 28.4 cM
Alliance:	Drd1tm1Stl page

Germline Transmission:	Earliest citation of germline transmission: J:21603
Parent Cell Line:	E14 (ES Cell)
Strain of Origin:	129P2/OlaHsd

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion     A PGK-neomycin based targeting vector replaced the 95% of the coding region. (J:21603)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

3 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Drd1 Mutation:	68 strains or lines available

Original:	J:21603 Xu M, et al., Dopamine D1 receptor mutant mice are deficient in striatal expression of dynorphin and in dopamine-mediated behavioral responses. Cell. 1994 Nov 18;79(4):729-42
All:	27 reference(s)