Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol: Neurog3tm1Fgu Name: neurogenin 3; targeted mutation 1, Francois Guillemot MGI ID: MGI:2159017 Synonyms: ngn3 -, Ngn3neo Gene: Neurog3  Location: Chr10:61968869-61970542 bp, + strand  Genetic Position: Chr10, 32.35 cM, cytoband B4 Alliance: Neurog3tm1Fgu page

Loss of enteroendocrine cells in Neurog3tm1Fgu/Neurog3tm3.1Ggr Tg(Vil1-cre)20Syr/0 and Neurog3tm3.1Ggr/Neurog3tm3.1Ggr Tg(Vil1-cre)20Syr/0 mice Show the 6 phenotype image(s) involving this allele.

Germline Transmission:	Earliest citation of germline transmission: J:60642
Parent Cell Line:	R1 (ES Cell)
Strain of Origin:	(129X1/SvJ x 129S1/Sv)F1-Kitl+

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: A neomycin selection cassette replaced a 628 bp DNA segment containing 468 bp of coding sequence, including sequences corresponding to the bHLH domain.

View phenotypes and curated references for all genotypes (concatenated display).

In Mice Carrying this Mutation:	16 assay results 1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	13 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Neurog3 Mutation:	18 strains or lines available

Original:	J:60642 Gradwohl G, et al., neurogenin3 is required for the development of the four endocrine cell lineages of the pancreas. Proc Natl Acad Sci U S A. 2000 Feb 15;97(4):1607-11
All:	17 reference(s)