Summary | Mutation origin | Mutation description | Phenotypes | Find Mice (IMSR) | References

Symbol:	Neurod6tm1Kan
Name:	neurogenic differentiation 6; targeted mutation 1, Klaus-Armin Nave
MGI ID:	MGI:2159008
Synonyms:	NEX -
Gene:	Neurod6  Location: Chr6:55654807-55658248 bp, - strand  Genetic Position: Chr6, 27.53 cM
Alliance:	Neurod6tm1Kan page

Germline Transmission:	Earliest citation of germline transmission: J:45777
Parent Cell Line:	R1 (ES Cell)
Strain of Origin:	(129X1/SvJ x 129S1/Sv)F1-Kitl+

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: A neomycin selection cassette replaced a genomic fragment containing most of the coding region, including amino acids 53-337 encoding the bHLH domain. Northern blot analysis on brain RNA derived from P5 homozygous mice demonstrated that no detectable transcript is produced from this allele. (J:45777)

View phenotypes and curated references for all genotypes (concatenated display).

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Neurod6 Mutation:	17 strains or lines available

Original:	J:45777 Schwab MH, et al., Neuronal basic helix-loop-helix proteins (NEX, neuroD, NDRF): spatiotemporal expression and targeted disruption of the NEX gene in transgenic mice. J Neurosci. 1998 Feb 15;18(4):1408-18
All:	2 reference(s)