Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Calb2tm1Map
Name:	calbindin 2; targeted mutation 1, Marc Parmentier
MGI ID:	MGI:2158756
Synonyms:	Cr -
Gene:	Calb2  Location: Chr8:110869158-110894844 bp, - strand  Genetic Position: Chr8, 57.44 cM
Alliance:	Calb2tm1Map page

Germline Transmission:	Earliest citation of germline transmission: J:42924
Parent Cell Line:	E14 (ES Cell)
Strain of Origin:	129P2/OlaHsd

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: A neomycin selection cassette replaced 31 bp of the second exon. Northern blot analysis on brain samples derived from homozygous mice demonstrated that no detectable transcript was produced from this allele. Western blot analysis on brain and ocular globe samples derived from homozygous mice confirmed that no detectable protein was made. (J:42924)

View phenotypes and curated references for all genotypes (concatenated display).

In Mice Carrying this Mutation:

1 assay results

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Calb2 Mutation:	23 strains or lines available

Original:	J:42924 Schurmans S, et al., Impaired long-term potentiation induction in dentate gyrus of calretinin-deficient mice. Proc Natl Acad Sci U S A. 1997 Sep 16;94(19):10415-20
All:	17 reference(s)