Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Casp9tm1Flv
Name:	caspase 9; targeted mutation 1, Richard A Flavell
MGI ID:	MGI:2158755
Synonyms:	caspase 9-, caspase-9-
Gene:	Casp9  Location: Chr4:141520923-141543287 bp, + strand  Genetic Position: Chr4, 74.75 cM, cytoband E1
Alliance:	Casp9tm1Flv page

Germline Transmission:	Earliest citation of germline transmission: J:49088
Parent Cell Line:	W9.5/W95 (ES Cell)
Strain of Origin:	129S1/Sv-Oca2+ Tyr+ Kitl+

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: A 1 kb genomic fragment containing sequences encoding a motif essential for protein activity was replaced with a neomycin selection cassette. RT-PCR analysis on RNA derived from kidney of homozygous mice demonstrated that no detectable transcript was produced from this allele. (J:49088)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

11 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Casp9 Mutation:	20 strains or lines available

Original:	J:49088 Kuida K, et al., Reduced apoptosis and cytochrome c-mediated caspase activation in mice lacking caspase 9. Cell. 1998 Aug 7;94(3):325-37
All:	32 reference(s)