Summary | Mutation origin | Mutation description | Phenotypes | Disease models | Find Mice (IMSR) | References

Symbol:	Scnn1atm1Rss
Name:	sodium channel, nonvoltage-gated 1 alpha; targeted mutation 1, Bernard C Rossier
MGI ID:	MGI:2158700
Synonyms:	alphaENaC -, Scnn1atm1
Gene:	Scnn1a  Location: Chr6:125297622-125321906 bp, + strand  Genetic Position: Chr6, 59.32 cM
Alliance:	Scnn1atm1Rss page

Germline Transmission:	Earliest citation of germline transmission: J:31762
Parent Cell Line:	HM-1 (ES Cell)
Strain of Origin:	129P2/OlaHsd-Hprt1b-m3

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: A genomic fragment containing part of exon 1 and sequences encoding the first transmembrane loop and most of the ectocytoplasmic loop was replaced with a neomycin selection cassette. RT-PCR analysis on samples derived from lung, liver and kidney tissue of homozygous mice confirmed that no detectable transcript is produced from this allele. (J:31762)

View phenotypes and curated references for all genotypes (concatenated display).

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Scnn1a Mutation:	27 strains or lines available

Original:	J:31762 Hummler E, et al., Early death due to defective neonatal lung liquid clearance in alpha-ENaC-deficient mice. Nat Genet. 1996 Mar;12(3):325-8
All:	13 reference(s)