Summary | Mutation origin | Mutation description | Expression | Phenotypes | Disease models | Tumor data | Find Mice (IMSR) | References

Symbol:	Irs2tm1Mfw
Name:	insulin receptor substrate 2; targeted mutation 1, Morris F White
MGI ID:	MGI:2158686
Synonyms:	Irs2-
Gene:	Irs2  Location: Chr8:11034681-11058458 bp, - strand  Genetic Position: Chr8, 5.35 cM
Alliance:	Irs2tm1Mfw page

Germline Transmission:	Earliest citation of germline transmission: J:46134
Parent Cell Line:	R1 (ES Cell)
Strain of Origin:	(129X1/SvJ x 129S1/Sv)F1-Kitl+

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: A targeting vector containing a PGK-neomycin cassette replaced the entire gene. Lack of protein was demonstrated in liver and muscle extracts by Western analysis in homozygous mutant animals. (J:46134)

View phenotypes and curated references for all genotypes (concatenated display).

In Mice Carrying this Mutation:	2 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	12 anatomical structure(s)

List all tumor models in MMHCdb carrying Irs2tm1Mfw

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Irs2 Mutation:	35 strains or lines available

Original:	J:46134 Withers DJ, et al., Disruption of IRS-2 causes type 2 diabetes in mice. Nature. 1998 Feb 26;391(6670):900-4
All:	61 reference(s)