Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | Notes | References

Symbol:	Flt3ltm1Imx
Name:	FMS-like tyrosine kinase 3 ligand; targeted mutation 1, Immunex Corporation
MGI ID:	MGI:2158499
Synonyms:	FL-, Flt3-L-, FLT3L-
Gene:	Flt3l  Location: Chr7:44780607-44785914 bp, - strand  Genetic Position: Chr7, 29.14 cM, cytoband B2-C
Alliance:	Flt3ltm1Imx page

Germline Transmission:	Earliest citation of germline transmission: J:62536
Parent Cell Line:	Not Specified (ES Cell)
Strain of Origin:	C57BL/6

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: A neomycin selection cassette replaced a genomic fragment containing the initiation codon and most of the sequences encoding the extracellular domain. RT-PCR analysis on RNA derived from spleen and bone marrow of homozygous mice confirmed that no detectable transcript is produced from this allele. (J:62536)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

4 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Flt3l Mutation:	11 strains or lines available

Original:	J:62536 McKenna HJ, et al., Mice lacking flt3 ligand have deficient hematopoiesis affecting hematopoietic progenitor cells, dendritic cells, and natural killer cells. Blood. 2000 Jun 1;95(11):3489-97
All:	92 reference(s)