Bmpr1btm1Kml
Targeted Allele Detail
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Symbol: |
Bmpr1btm1Kml |
Name: |
bone morphogenetic protein receptor, type 1B; targeted mutation 1, Karen M Lyons |
MGI ID: |
MGI:2158497 |
Synonyms: |
Bmpr1b-, Bmpr1bn, BmprIB - |
Gene: |
Bmpr1b Location: Chr3:141542897-141875186 bp, - strand Genetic Position: Chr3, 66.11 cM
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Alliance: |
Bmpr1btm1Kml page
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Skeletal abnormalities in Bmpr1btm1Kml/Bmpr1btm1Kml, Bmpr1atm2.1Bhr/Bmpr1atm2.1Bhr Tg(Col2a1-cre)1Bhr/?, and Bmpr1atm2.1Bhr/Bmpr1atm2.1Bhr Bmpr1btm1Kml/Bmpr1btm1Kml Tg(Col2a1-cre)1Bhr/? mice
Show the 4 phenotype image(s) involving this allele.
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Germline Transmission: |
Earliest citation of germline transmission:
J:59282
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Parent Cell Line: |
CCE/EK.CCE (ES Cell)
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Strain of Origin: |
129S/SvEv-Gpi1c
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Allele Type: |
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Targeted (Null/knockout) |
Mutations: |
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Insertion, Intragenic deletion
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Mutation details: A genomic fragment containing the first coding exon was replaced with a neomycin selection cassette. RT-PCR analysis on total embryo RNA from homozygous embryos demonstrated that an aberrant transcript is produced from this allele, but the authors predict that no functional protein can be produced.
(J:59282)
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View phenotypes and curated references for all genotypes (concatenated display).
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Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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Carrying any Bmpr1b Mutation: |
37 strains or lines available
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Original: |
J:59282 Yi SE, et al., The type I BMP receptor BMPRIB is required for chondrogenesis in the mouse limb. Development. 2000 Feb;127(3):621-30 |
All: |
39 reference(s) |
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