Lmx1btm1Rjo
Targeted Allele Detail
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Symbol: |
Lmx1btm1Rjo |
Name: |
LIM homeobox transcription factor 1 beta; targeted mutation 1, Randy L Johnson |
MGI ID: |
MGI:2158463 |
Synonyms: |
Lmx1b-, Lmxbneo |
Gene: |
Lmx1b Location: Chr2:33450977-33530620 bp, - strand Genetic Position: Chr2, 22.48 cM
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Alliance: |
Lmx1btm1Rjo page
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Retarded development of the glomerular capillaries in Lmx1btm1Rjo/Lmx1btm1Rjo mice
Show the 6 phenotype image(s) involving this allele.
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Germline Transmission: |
Earliest citation of germline transmission:
J:47316
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Parent Cell Line: |
AB1 (ES Cell)
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Strain of Origin: |
129S7/SvEvBrd-Hprt1+
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Allele Type: |
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Targeted (Null/knockout) |
Mutations: |
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Insertion, Intragenic deletion
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Mutation details: A PGK-neomycin resistance cassette replaced about 5 kb of sequence including exons 3-7, which encode the second LIM domain, the homeodomain, and most of the carboxy-terminal region. RT-PCR analysis did not detect transcript from the region encoding the homeodomain in homozygous mutant 10 dpc embryos.
(J:47316)
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View phenotypes and curated references for all genotypes (concatenated display).
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Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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Carrying any Lmx1b Mutation: |
16 strains or lines available
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Original: |
J:47316 Chen H, et al., Limb and kidney defects in Lmx1b mutant mice suggest an involvement of LMX1B in human nail patella syndrome. Nat Genet. 1998 May;19(1):51-5 |
All: |
39 reference(s) |
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