Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Pxntm1Smth
Name:	paxillin; targeted mutation 1, Sheila M Thomas
MGI ID:	MGI:2158458
Synonyms:	paxillin-
Gene:	Pxn  Location: Chr5:115644735-115694046 bp, + strand  Genetic Position: Chr5, 56.1 cM
Alliance:	Pxntm1Smth page

Germline Transmission:	Earliest citation of germline transmission: J:73970
Parent Cell Line:	AK7 (ES Cell)
Strain of Origin:	129S4/SvJaeSor

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: The allele replaces 1.6 kb of the endogenous gene with the SA-beta-geo construct. Exons 2 and 3, corresponding to amino acids 5-74, are deleted from the locus. Immunoblot analysis did not detect protein in lysates prepared from homozygous mutant embryos. (J:73970)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

8 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Pxn Mutation:	61 strains or lines available

Original:	J:73970 Hagel M, et al., The adaptor protein paxillin is essential for normal development in the mouse and is a critical transducer of fibronectin signaling. Mol Cell Biol. 2002 Feb;22(3):901-15
All:	2 reference(s)