Summary | Mutation origin | Mutation description | Expression | Phenotypes | Disease models | Find Mice (IMSR) | References

Symbol:	Slc12a1tm1Tkh
Name:	solute carrier family 12, member 1; targeted mutation 1, Nobuyuki Takahashi
MGI ID:	MGI:2158359
Synonyms:	NKCC2-, Slc12a1tm1Unc
Gene:	Slc12a1  Location: Chr2:124994430-125071922 bp, + strand  Genetic Position: Chr2, 61.23 cM
Alliance:	Slc12a1tm1Tkh page

Germline Transmission:	Earliest citation of germline transmission: J:62224
Parent Cell Line:	TC1/TC-1 (ES Cell)
Strain of Origin:	129S6/SvEvTac

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: A 12 kb genomic fragment containing the promoter and exons 1-3 was replaced with a neomycin selection cassette. Western blot analysis on kidney proteins derived from homozygous mice demonstrated that no protein is produced from this allele. (J:62224)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

4 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 2 strains available      Cell Lines: 0 lines available
Carrying any Slc12a1 Mutation:	55 strains or lines available

Original:	J:62224 Takahashi N, et al., Uncompensated polyuria in a mouse model of Bartter's syndrome. Proc Natl Acad Sci U S A. 2000 May 9;97(10):5434-9
All:	4 reference(s)