Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol: Gulotm1Mae Name: gulonolactone (L-) oxidase; targeted mutation 1, Nobuyo Maeda MGI ID: MGI:2158350 Synonyms: gulo-, Gulotm1Unc Gene: Gulo  Location: Chr14:66224235-66246656 bp, - strand  Genetic Position: Chr14, 34.36 cM Alliance: Gulotm1Mae page

Abnormalities in the aorta of Gulotm1Mae/Gulotm1Mae mice Show the 3 phenotype image(s) involving this allele.

Germline Transmission:	Earliest citation of germline transmission: J:59931
Parent Cell Line:	Not Specified (ES Cell)
Strain of Origin:	Not Specified

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: A genomic fragment containing exons 3 and 4 was replaced with a neomycin selection cassette. Northern blot analysis confirmed that no detectable transcript is produced from this allele in liver of homozygous mice. (J:59931)

View phenotypes and curated references for all genotypes (concatenated display).

In Mice Carrying this Mutation:	3 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	9 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 2 strains available      Cell Lines: 0 lines available
Carrying any Gulo Mutation:	27 strains or lines available

Original:	J:59931 Maeda N, et al., Aortic wall damage in mice unable to synthesize ascorbic acid. Proc Natl Acad Sci U S A. 2000 Jan 18;97(2):841-6
All:	41 reference(s)