Summary | Mutation origin | Mutation description | Phenotypes | Find Mice (IMSR) | References

Symbol:	Xiaptm1Thsn
Name:	X-linked inhibitor of apoptosis; targeted mutation 1, Craig B Thompson
MGI ID:	MGI:2158344
Synonyms:	Xiap-, XIAP deficient
Gene:	Xiap  Location: ChrX:41148556-41198533 bp, + strand  Genetic Position: ChrX, 23.19 cM, cytoband A3-A5
Alliance:	Xiaptm1Thsn page

Germline Transmission:	Earliest citation of germline transmission: J:74251
Parent Cell Line:	R1 (ES Cell)
Strain of Origin:	(129X1/SvJ x 129S1/Sv)F1-Kitl+

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: A genomic fragment containing exon 1 was replaced with a neomycin selection cassette inserted in reverse transcriptional orientation to the gene. Northern blot analysis demonstrated that that no detectable transcript was present in kidney or liver tissue of homozygous mice, and western blot analysis confirmed that no detectable protein was present in embryonic fibroblasts derived from homozygous mice. (J:74251)

View phenotypes and curated references for all genotypes (concatenated display).

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Xiap Mutation:	37 strains or lines available

Original:	J:74251 Harlin H, et al., Characterization of XIAP-deficient mice. Mol Cell Biol. 2001 May;21(10):3604-8
All:	28 reference(s)