Summary | Mutation origin | Mutation description | Expression | Phenotypes | Disease models | Find Mice (IMSR) | References

Symbol:	Nr4a2tm1Tpe
Name:	nuclear receptor subfamily 4, group A, member 2; targeted mutation 1, Thomas Perlmann
MGI ID:	MGI:2157566
Synonyms:	Nurr1-
Gene:	Nr4a2  Location: Chr2:56996845-57014018 bp, - strand  Genetic Position: Chr2, 31.66 cM
Alliance:	Nr4a2tm1Tpe page

Germline Transmission:	Earliest citation of germline transmission: J:39661
Parent Cell Line:	E14 (ES Cell)
Strain of Origin:	129P2/OlaHsd

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: Insertion of a neomycin resistance cassette replaces the sequence encoding the N terminal transactivation and DNA binding domains (exons 2,3 and part of 4). In situ hybridization detected no transcript from this gene in homozygous mutant mice. (J:39661)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

1 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Nr4a2 Mutation:	40 strains or lines available

Original:	J:39661 Zetterstrom RH, et al., Dopamine neuron agenesis in Nurr1-deficient mice [see comments]. Science. 1997 Apr 11;276(5310):248-50
All:	20 reference(s)