Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Il1rntm1Yiw
Name:	interleukin 1 receptor antagonist; targeted mutation 1, Yoichiro Iwakura
MGI ID:	MGI:2157397
Synonyms:	IL-1Ra-, IL-1ra KO
Gene:	Il1rn  Location: Chr2:24226872-24241503 bp, + strand  Genetic Position: Chr2, 16.36 cM
Alliance:	Il1rntm1Yiw page

Germline Transmission:	Earliest citation of germline transmission: J:47429
Parent Cell Line:	R1 (ES Cell)
Strain of Origin:	(129X1/SvJ x 129S1/Sv)F1-Kitl+

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: A PGK-neomycin resistance cassette replaced all the coding regions for the secreted form of the protein. Northern blot analysis of activated peritoneal macrophages did not detect transcript in homozygous mutant mice. (J:47429)

View phenotypes and curated references for all genotypes (concatenated display).

In Mice Carrying this Mutation:	2 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	1 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Il1rn Mutation:	23 strains or lines available

Original:	J:47429 Horai R, et al., Production of mice deficient in genes for interleukin (IL)-1alpha, IL-1beta, IL-1alpha/beta, and IL-1 receptor antagonist shows that IL-1beta is crucial in turpentine-induced fever development and glucocorticoid secretion. J Exp Med. 1998 May 4;187(9):1463-75
All:	50 reference(s)