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Bcl2l11tm1.1Ast
Targeted Allele Detail
Summary
Symbol: Bcl2l11tm1.1Ast
Name: BCL2 like 11; targeted mutation 1.1, Andreas Strasser
MGI ID: MGI:2156498
Synonyms: bim-
Gene: Bcl2l11  Location: Chr2:127967958-128004467 bp, + strand  Genetic Position: Chr2, 62.23 cM, cytoband F3-G1
Alliance: Bcl2l11tm1.1Ast page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:58641
Parent Cell Line:  W9.5/W95 (ES Cell)
Strain of Origin:  129S1/Sv-Oca2+ Tyr+ Kitl+
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsInsertion of a floxed PGK-neomycin cassette deleted the exon encoding the BH3 domain. Cre-mediated recombination in vivo subsequently removed the inserted cassette. In the final allele a single loxP site remains in place of the exon. Immunoblot analysis using a rat monoclonal antibody did not detect full-length protein, but did detect a small amount of a truncated polypeptide in spleen cells from homozygous mutant mice. (J:58641)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Mice Carrying this Mutation: 1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation: 8 anatomical structure(s)
Tumor Data
List all tumor models in MMHCdb carrying Bcl2l11tm1.1Ast
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 4 strains available      Cell Lines: 0 lines available
Carrying any Bcl2l11 Mutation:  32 strains or lines available
References
Original:  J:58641 Bouillet P, et al., Proapoptotic Bcl-2 relative Bim required for certain apoptotic responses, leukocyte homeostasis, and to preclude autoimmunity. Science. 1999 Nov 26;286(5445):1735-8
All:  211 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/12/2024
MGI 6.23
The Jackson Laboratory