Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol: Epha4tm1Byd Name: Eph receptor A4; targeted mutation 1, Andrew W Boyd MGI ID: MGI:2156472 Synonyms: Epha4-, Epha4KO Gene: Epha4  Location: Chr1:77343822-77491725 bp, - strand  Genetic Position: Chr1, 39.55 cM, cytoband C1-C5 Alliance: Epha4tm1Byd page

Disruption of spinal cord architecture and the anterior commissure in Epha4tm1Byd/Epha4tm1Byd mice Show the 2 phenotype image(s) involving this allele.

Germline Transmission:	Earliest citation of germline transmission: J:50573
Parent Cell Line:	W9.5/W95 (ES Cell)
Strain of Origin:	129S1/Sv-Oca2+ Tyr+ Kitl+

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: A neomycin selection cassette replaced exon 3, corresponding to nucleotides 217-880 of the encoded transcript. Immunohistochemical analysis on E8.5 embryos demonstrated that the encoded protein was not detectable in rhomdomeres of homozygous mice. (J:50573)

View phenotypes and curated references for all genotypes (concatenated display).

In Mice Carrying this Mutation:	7 assay results
In Structures Affected by this Mutation:	6 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Epha4 Mutation:	66 strains or lines available

Original:	J:50573 Dottori M, et al., EphA4 (Sek1) receptor tyrosine kinase is required for the development of the corticospinal tract. Proc Natl Acad Sci U S A. 1998 Oct 27;95(22):13248-53
All:	40 reference(s)