Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Adam3tm1Ihgg
Name:	ADAM metallopeptidase domain 3; targeted mutation 1, Institut fur Humangenetik
MGI ID:	MGI:2156166
Synonyms:	Cyrn -
Gene:	Adam3  Location: Chr8:25167241-25215868 bp, - strand  Genetic Position: Chr8, 13.09 cM, cytoband A2
Alliance:	Adam3tm1Ihgg page

Germline Transmission:	Earliest citation of germline transmission: J:58730
Parent Cell Line:	R1 (ES Cell)
Strain of Origin:	(129X1/SvJ x 129S1/Sv)F1-Kitl+

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: A genomic fragment containing exon 3 was replaced with a neomycin selection cassette in opposite transcriptional orientation to the gene. RT-PCR analysis detected the presence of a trancript that spliced exon 2 to 4, but this mutation introduces a frameshift and premature stop codon. Western blots on testicular extracts confirmed the absence of the full length protein in homozygous mice. (J:58730)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

1 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Adam3 Mutation:	61 strains or lines available

Original:	J:58730 Shamsadin R, et al., Male mice deficient for germ-cell cyritestin are infertile. Biol Reprod. 1999 Dec;61(6):1445-51
All:	3 reference(s)