Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol: Gjb2tm1Kwi Name: gap junction protein, beta 2; targeted mutation 1, Klaus Willecke MGI ID: MGI:2155739 Gene: Gjb2  Location: Chr14:57336059-57342159 bp, - strand  Genetic Position: Chr14, 30.1 cM, cytoband D1-E1 Alliance: Gjb2tm1Kwi page

Small size of Gjb2tm1Kwi/Gjb2tm1Kwi embryos Show the 2 phenotype image(s) involving this allele.

Germline Transmission:	Earliest citation of germline transmission: J:46665
Parent Cell Line:	E14.1 (ES Cell)
Strain of Origin:	129P2/OlaHsd

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: A 1065 bp genomic fragment within exon 2, corresponding to amino acids 83-226, was replaced with a neomycin resistance cassette. (J:46665)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

2 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Gjb2 Mutation:	21 strains or lines available

Original:	J:46665 Gabriel HD, et al., Transplacental uptake of glucose is decreased in embryonic lethal connexin26-deficient mice. J Cell Biol. 1998 Mar 23;140(6):1453-61
All:	1 reference(s)