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Ube4a Gene Detail
Summary
  • Symbol
    Ube4a
  • Name
    ubiquitination factor E4A
  • Synonyms
    4732444G18Rik, 9930123J21Rik, UFD2b
  • Feature Type
    protein coding gene
  • IDs
    MGI:2154580
    NCBI Gene: 140630
  • Alliance
    gene page
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr9:44834425-44876898 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 9, 24.84 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    452 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2154580
 protein coding gene Chr9:44834425-44877021 (-)
129S1/SvImJ MGP_129S1SvImJ_G0034723
 protein coding gene Chr9:43454116-43498156 (-)
A/J MGP_AJ_G0034704
 protein coding gene Chr9:42234837-42278015 (-)
AKR/J MGP_AKRJ_G0034631
 protein coding gene Chr9:43110826-43154199 (-)
BALB/cJ MGP_BALBcJ_G0034695
 protein coding gene Chr9:41974881-42017571 (-)
C3H/HeJ MGP_C3HHeJ_G0034406
 protein coding gene Chr9:43563474-43607143 (-)
C57BL/6NJ MGP_C57BL6NJ_G0035216
 protein coding gene Chr9:44737000-44780476 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0032131
 protein coding gene Chr9:41794604-41836628 (-)
CAST/EiJ MGP_CASTEiJ_G0033728
 protein coding gene Chr9:43423371-43468548 (-)
CBA/J MGP_CBAJ_G0034378
 protein coding gene Chr9:46366650-46412015 (-)
DBA/2J MGP_DBA2J_G0034537
 protein coding gene Chr9:42130832-42173356 (-)
FVB/NJ MGP_FVBNJ_G0034478
 protein coding gene Chr9:41393722-41436003 (-)
LP/J MGP_LPJ_G0034618
 protein coding gene Chr9:43752373-43796296 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0034522
 protein coding gene Chr9:48205789-48249518 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0035237
 protein coding gene Chr9:43034335-43076978 (-)
PWK/PhJ MGP_PWKPhJ_G0033433
 protein coding gene Chr9:42017747-42060244 (-)
SPRET/EiJ MGP_SPRETEiJ_G0033269
 protein coding gene Chr9:43322914-43366512 (-)
WSB/EiJ MGP_WSBEiJ_G0033841
 protein coding gene Chr9:43061007-43104848 (-)



Homology
more
  • Human Ortholog
    UBE4A, ubiquitination factor E4A
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    UBE4A, ubiquitination factor E4A
  • Synonyms
    E4, NEDHMS, UBOX2, UFD2
  • Links
    NCBI Gene ID: 9354
    neXtProt AC: NX_Q14139
    UniProt: Q14139

  • Chr Location
    11q23.3; chr11:118359600-118399211 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    8 phenotypes from 1 allele in 1 genetic background
    7 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    11
  • GO References
    3
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    843
  • Tissues
    15
  • cDNA Data
    10
  • Literature Summary
    1
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000059890 Ensembl Gene Model | MGI Sequence Detail 42474 C57BL/6J ±  kb
    transcript ENSMUST00000117549 Ensembl | MGI Sequence Detail 3415 Not Applicable  
    polypeptide ENSMUSP00000112632 Ensembl | MGI Sequence Detail 1085 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 12
      Genomic 1
      cDNA 11

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGI:2441667, MGI:2443449
    References
    more
    • Summaries
      All 30
      Developmental Gene Expression 1
      Gene Ontology 3
      Phenotypes 7
    • Earliest
      J:71263 Hatakeyama S, et al., U box proteins as a new family of ubiquitin-protein ligases. J Biol Chem. 2001 Aug 31;276(35):33111-20
    • Latest
      J:345016 Penniman CM, et al., Loss of FoxOs in muscle increases strength and mitochondrial function during aging. J Cachexia Sarcopenia Muscle. 2023 Feb;14(1):243-259
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    04/09/2024
    MGI 6.23     		The Jackson Laboratory