Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Cav1tm1Kur
Name:	caveolin 1, caveolae protein; targeted mutation 1, Teymuras V Kurzchalia
MGI ID:	MGI:2154537
Synonyms:	Cav-, cav-1-, Cav-1 KO
Gene:	Cav1  Location: Chr6:17306387-17341323 bp, + strand  Genetic Position: Chr6, 7.73 cM, cytoband A2
Alliance:	Cav1tm1Kur page

Germline Transmission:	Earliest citation of germline transmission: J:71760
Parent Cell Line:	Not Specified (ES Cell)
Strain of Origin:	129X1/SvJ

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: A neomycin resistance cassette replaced a genomic fragment containing exon 3, which encodes the transmembrane domain, the palmitoylation sites and the scaffolding domains. RT-PCR analysis revealed that no transcript was present in lung total RNA derived from homozygous mice, and western blot analysis demonstrated that no protein was detectable in lung and heart extracts from homozygous mice. (J:71760)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

5 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Cav1 Mutation:	29 strains or lines available

Original:	J:71760 Drab M, et al., Loss of caveolae, vascular dysfunction, and pulmonary defects in caveolin-1 gene-disrupted mice. Science. 2001 Sep 28;293(5539):2449-52
All:	58 reference(s)