Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Abl2tm1Ajk
Name:	ABL proto-oncogene 2, non-receptor tyrosine kinase; targeted mutation 1, Anthony J Koleske
MGI ID:	MGI:2153719
Synonyms:	arg -
Gene:	Abl2  Location: Chr1:156386356-156477138 bp, + strand  Genetic Position: Chr1, 67.71 cM
Alliance:	Abl2tm1Ajk page

Germline Transmission:	Earliest citation of germline transmission: J:51887
Parent Cell Line:	J1 (ES Cell)
Strain of Origin:	129S4/SvJae

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: The sequences encoding amino acids 287-320, corresponding to the N-terminal portion of the kinase domain, were replaced with a neomycin selection cassette. Western blot analysis demonstrated the absence of the protein in tissue extracts derived from homozygous mice. (J:51887)

View phenotypes and curated references for all genotypes (concatenated display).

In Mice Carrying this Mutation:	38 assay results
In Structures Affected by this Mutation:	2 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Abl2 Mutation:	79 strains or lines available

Original:	J:51887 Koleske AJ, et al., Essential roles for the Abl and Arg tyrosine kinases in neurulation. Neuron. 1998 Dec;21(6):1259-72
All:	19 reference(s)