Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Matn1tm1Goe
Name:	matrilin 1, cartilage matrix protein; targeted mutation 1, Paul F Goetinck
MGI ID:	MGI:2153042
Synonyms:	mat-1tm1Goe, Matn1-
Gene:	Matn1  Location: Chr4:130671696-130682786 bp, + strand  Genetic Position: Chr4, 64.09 cM
Alliance:	Matn1tm1Goe page

Germline Transmission:	Earliest citation of germline transmission: J:58843
Parent Cell Line:	J1 (ES Cell)
Strain of Origin:	129S4/SvJae

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: A neomycin cassette replaced exon 4 and part of exon 5. In situ hybridization and immunohistochemical analysis in distal growth plates of E15 homozygous embryos demonstrated an absence of transcript and protein. (J:58843)

View phenotypes and curated references for all genotypes (concatenated display).

In Mice Carrying this Mutation:	5 assay results
In Structures Affected by this Mutation:	2 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Matn1 Mutation:	20 strains or lines available

Original:	J:58843 Huang X, et al., Mice lacking matrilin-1 (cartilage matrix protein) have alterations in type II collagen fibrillogenesis and fibril organization. Dev Dyn. 1999 Dec;216(4-5):434-41
All:	3 reference(s)