Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Dnah11tm1Ssp
Name:	dynein, axonemal, heavy chain 11; targeted mutation 1, S Steven Potter
MGI ID:	MGI:2152963
Synonyms:	lrd -, lrddeltaP1
Gene:	Dnah11  Location: Chr12:117841717-118162778 bp, - strand  Genetic Position: Chr12, 63.25 cM
Alliance:	Dnah11tm1Ssp page

Germline Transmission:	Earliest citation of germline transmission: J:44522
Parent Cell Line:	Not Specified (ES Cell)
Strain of Origin:	Not Specified

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: A neomycin selection cassette replaced a genomic fragemnt that contained two exons that encode the first P-loop. RT-PCR analysis on RNA derived from brain of homozygous mice demonstrated that an aberrant transcript was made that spliced around the missing exons to generate an mRNA that maintained an in-frame deletion. (J:44522)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

4 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Dnah11 Mutation:	217 strains or lines available

Original:	J:44522 Supp DM, et al., Targeted deletion of the ATP binding domain of left-right dynein confirms its role in specifying development of left-right asymmetries. Development. 1999 Dec;126(23):5495-504
All:	1 reference(s)