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Gnai3tm1Rmm
Targeted Allele Detail
Summary
Symbol: Gnai3tm1Rmm
Name: G protein subunit alpha i3; targeted mutation 1, Richard M Mortensen
MGI ID: MGI:2152618
Gene: Gnai3  Location: Chr3:108014596-108053462 bp, - strand  Genetic Position: Chr3, 46.83 cM
Alliance: Gnai3tm1Rmm page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:68045
Parent Cell Line:  J1 (ES Cell)
Strain of Origin:  129S4/SvJae
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutation:    Insertion
 
Mutation detailsA neomycin resistance cassette was inserted into exon 1. Western analysis confirmed the elimination of expression in homozygous mice and detected no compensatory changes in other pertussis toxin sensitive G proteins. (J:68045)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Gnai3 Mutation:  28 strains or lines available
References
Original:  J:68045 Jain M, et al., Targeted inactivation of Galpha(i) does not alter cardiac function or beta-adrenergic sensitivity. Am J Physiol Heart Circ Physiol. 2001 Feb;280(2):H569-75
All:  5 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/19/2024
MGI 6.23
The Jackson Laboratory