Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Map2tm1Noh
Name:	microtubule-associated protein 2; targeted mutation 1, Nobutaka Hirokawa
MGI ID:	MGI:2152587
Synonyms:	map2-
Gene:	Map2  Location: Chr1:66214432-66481742 bp, + strand  Genetic Position: Chr1, 33.49 cM
Alliance:	Map2tm1Noh page

Germline Transmission:	Earliest citation of germline transmission: J:71900
Parent Cell Line:	Not Specified (ES Cell)
Strain of Origin:	Not Specified

Allele Type:    Targeted (Null/knockout) Mutation:    Insertion   Mutation details: Insertion of a neomycin resistance cassette disrupted the exon that encodes the first microtubule-binding repeat. This exon corresponds to exon 15 of the human MAP2 gene. Western analysis did not detect protein in brain of eight week old homozygous mutant mice. (J:71900)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

2 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Map2 Mutation:	108 strains or lines available

Original:	J:71900 Teng J, et al., Synergistic effects of MAP2 and MAP1B knockout in neuronal migration, dendritic outgrowth, and microtubule organization. J Cell Biol. 2001 Oct 1;155(1):65-76
All:	4 reference(s)