Summary | Mutation origin | Mutation description | Expression | Phenotypes | Tumor data | Find Mice (IMSR) | References

Symbol:	Grb2tm1Paw
Name:	growth factor receptor bound protein 2; targeted mutation 1, Tony Pawson
MGI ID:	MGI:2152451
Synonyms:	deltaGrb2, Grb2-
Gene:	Grb2  Location: Chr11:115534871-115599423 bp, - strand  Genetic Position: Chr11, 80.91 cM
Alliance:	Grb2tm1Paw page

Germline Transmission:	Earliest citation of germline transmission: J:51424
Parent Cell Line:	R1 (ES Cell)
Strain of Origin:	(129X1/SvJ x 129S1/Sv)F1-Kitl+

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: A genomic fragment containing exons 2 and 3 was replaced with a vector containing a neomycin selection cassette by homologous recombination. Immunoprecipitation and western blotting experiments on cell lysates derived from homozygous mice confirmed that no detectable protein was made from this allele. (J:51424)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

3 anatomical structure(s)

List all tumor models in MMHCdb carrying Grb2tm1Paw

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Grb2 Mutation:	42 strains or lines available

Original:	J:51424 Cheng AM, et al., Mammalian Grb2 regulates multiple steps in embryonic development and malignant transformation. Cell. 1998 Dec 11;95(6):793-803
All:	14 reference(s)